‘Paxlovid rebound’ cases have experts scrambling for answers
‘Paxlovid rebound’ cases have experts scrambling for answers
Several cases have been reported of COVID-19 patients complaining of a relapse of symptoms a week after ‘recovering’ at the end of a five-day course of Paxlovid, an antiviral drug by Pfizer Inc.
The reason for such ‘Paxlovid relapse’ is unclear. The pill, also known as nirmatrelvir-ritonavir, reduces risk of hospitalisations or death from COVID-19 by 89 per cent, the company had claimed citing data from studies involving those who were not vaccinated and were infected by the Delta variant.
The Omicron variant, currently common, has a higher viral load compared to its predecessors. This may well be the reason why many patients are relapsing after testing negative for the novel coronavirus, according to a new study. The preprint published in medRxiv May 24, 2022 aims to “characterise the virology of symptomatic rebound after nirmatrelvir-ritonavir”.
The study assessed seven individuals who reported ‘Paxlovid relapse’ and found live virus for up to 11 days after the completion of the treatment. This underlines the need to reassess monitoring and isolation guidelines since a relapse patient may still be infectious.
The Institute for Health Metrics and Evaluation (IHME), in an April 2022 update, stated that scaling up antivirals may result in 80-90 per cent fewer deaths from future variants more severe than omicron. But was pining all our hopes on this treatment a mistake?
The United States government is not tracking Paxlovid rebound cases as yet.
Another theory suggests a fundamentally different immune response against the variant and the different way in which it infects the body — limited to the upper respiratory tract — could be the reason for rebound cases.
The US Centre for Disease Control and Prevention (CDC) May 24 released an advisory addressing the issue. “There is currently no evidence that additional treatment is needed with Paxlovid or other anti-SARS-CoV-2 therapies in cases where COVID-19 rebound is suspected,” the body stated.
There’s still no clarity on the way forward but the antiviral pill’s efficacy still holds despite rebound cases.
“Drug resistance does not appear to be a significant contributor to relapse and suggest that nirmatrelvir ritonavir may retain activity in most cases of symptom recrudescence,” the authors of the preprint noted.
Related News & Content
-
Limit taxonomy terms added to a custom post type
Limit taxonomy terms added to a custom post type,I've created a Custom Post Type and a Custom Taxonomy. In WP Admin, how can I limit amount of taxonomy terms that are added to the custom post type? I want to add no more than one tag into the post. Tags: custom post types custom taxonomy limit stackexchange.com WordPress Development Stack Exchange -
Query top level custom post in taxonomy
Query top level custom post in taxonomy,This is my first post, I'm a bit stuck. I have a custom post (dan) and taxonomy (dnas), with hierarchical categories. I want to make a query resulting in posts at toplevel (hoofdcategorie01, Tags: stackexchange.com taxonomy WordPress Development Stack Exchange wp query -
Gutenberg: Restrict Top Level Blocks, But Not Child Blocks
Gutenberg: Restrict Top Level Blocks, But Not Child Blocks,Background I've created a custom top level "page section" block, to work with my existing theme. I've like to restrict top level blocks to ONLY that one block. However, I don't want to di... Tags: block editor stackexchange.com WordPress Development Stack Exchange -
How do I load styles into the block editor admin screen?
How do I load styles into the block editor admin screen?,The core file 'load-styles.php' generates css styles. Some of the styles interfere with the block editor. I would like to pass in my own style rules that override the styles generated by 'load-styl... Tags: block editor stackexchange.com WordPress Development Stack Exchange -
Installing WordPress in a subdirectory
Installing WordPress in a subdirectory,I am trying to install wordpress into a subdirectory of a website. I simply want to build the client's new site in this subdirectory, so a separate and new WP install in this subdirectory, and the... Tags: installation stackexchange.com WordPress Development Stack Exchange -
Custom theme and plugin updating
Custom theme and plugin updating,History: I'm working on a project for a client that involves building 27 unique websites that are built on wordpress. I say unique, because (for reasons that are not worth going into here) they ar... Tags: automatic updates plugin development stackexchange.com theme development WordPress Development Stack Exchange -
Rewrite nested urls for custom post type
Rewrite nested urls for custom post type,I have a problem with nested permalink. I have a structure of urls like that: Catalog -> Category -> Product My urls are: www.domain.com/catalogs (for archive catalog) www.domain.com/catal... Tags: custom post types stackexchange.com url rewriting WordPress Development Stack Exchange -
Ajax not working to insert, query and result data
Ajax not working to insert, query and result data,On my site, through a form I send/register same information in database, do a SELECT/query and return it! Return the last table saved in database, just that user just entered on the form (along wit... Tags: Ajax database functions plugin development stackexchange.com WordPress Development Stack Exchange -
Israel at war, day 204: Hamas airs video of Israeli hostages, one with U.S. citizenship
Israel at war, day 204: Hamas airs video of Israeli hostages, one with U.S. citizenship,Hamas Studying Israel's Response to Position on Cease-fire Talks Gaza Aid Shipments Resume From Cyprus IDF: Two Palestinians Killed After Firing on IDF Outpost in the West Bank Pro-Palestinian Protest Leader Banned From Columbia Campus Here's What You Need to Know 204 Days Into the War Tags: 2023 Israel Gaza War haaretz.com Israel News -
Carol Kirkwood stuns in figure-hugging dress amid BBC Breakfast technical chaos
Carol Kirkwood stuns in figure-hugging dress amid BBC Breakfast technical chaos,CAROL Kirkwood stunned in a figure-hugging dress amid a technical blunder. BBC Breakfast was flung into chaos this morning after a string of sound issues. However Carol, 61, was all smiles as she p… Tags: BBC BBC Breakfast BBC ONE Carol Kirkwood mirror.co.uk The Scottish Sun TV News TV UK daytime TV -
Families ‘to sue prison’ where loud inmates ‘terrorise kids’ with screaming
Families 'to sue prison' where loud inmates 'terrorise kids' with screaming,Residents living next door to a new prison who say their kids have to sleep wearing headphones and some leave during weekends due to the racket are threatening to sue the prison service Tags: mirror.co.uk Neighbours from hell prisons Scottish government The Mirror -
Doctor Strange’s Secret Wars Role May Be More Important Than You Thought – Looper
Doctor Strange's Secret Wars Role May Be More Important Than You Thought - Looper,According to entertainment leaker Alex Perez, Doctor Strange will find himself confronting his inner struggles as he headlines "Avengers: Secret Wars." Tags: Fiction Looper looper.com Marvel Cinematic Universe Science Star Wars The Universal Monsters franchise -
What Kris Jenner Has Said About Those O.J. Simpson Affair Rumors – Nicki Swift
What Kris Jenner Has Said About Those O.J. Simpson Affair Rumors - Nicki Swift,Over the years, plenty of gossip has swirled about the Kardashians. Here's what Kris Jenner has said on those affair rumors about O.J. Simpson. -
Why We’re Worried About Khloe Kardashian – Nicki Swift
Why We're Worried About Khloe Kardashian - Nicki Swift,Although Khloé Kardashian has seemingly picked up the pieces of her life after turmoil, there's no denying that we are still worried about the reality star. -
Joe Flaherty was the ‘only guy’ who could get Eugene Levy to break character
Joe Flaherty was the 'only guy' who could get Eugene Levy to break character,Eugene Levy says his 'SCTV' castmate Joe Flaherty was the only comedian who could get him to break character on stage. Tags: CTVNews ctvnews.ca Entertainment -
Kurt Cobain is still shaping culture – 30 years after the Nirvana frontman’s death
Kurt Cobain is still shaping culture – 30 years after the Nirvana frontman's death,Thirty years from his death on April 5 1994, the impact of Kurt Cobain and his band, Nirvana, and their values, still resonates in today’s culture and music. Tags: CTVNews ctvnews.ca Entertainment -
Canada’s emissions report shows progress toward 2030 goal, but still a long way to go
Canada's emissions report shows progress toward 2030 goal, but still a long way to go,Canada's latest greenhouse-gas emissions report shows the country making progress toward meeting its next target in 2030, but there is still a very long way to go. Tags: Climate and environment CTVNews ctvnews.ca -
McDonald’s buying back its franchises in Israel as boycott hurt sales
McDonald's buying back its franchises in Israel as boycott hurt sales,McDonald's says it's acquiring Alonyal, which owns 225 McDonald's restaurants in Israel that have been hit by calls for a boycott over the war with Hamas in Gaza. Tags: cbsmoneywatch cbsnews.com Gaza Strip Israel McDonald and 039;s MoneyWatch starbucks
Warning: file_get_contents(https://www.scienceradars.com/wp-output-content.php?pg=1&cat=&kw=&lvl=): Failed to open stream: HTTP request failed! HTTP/1.1 526 in /home/wwwroot/xuenou.com/wp-content/themes/chromenews/template-parts/content.php on line 169
Warning: file_get_contents(https://www.bayuexiang.com/wp-output-content.php?pg=1&cat=&kw=&lvl=): Failed to open stream: HTTP request failed! HTTP/1.1 526 in /home/wwwroot/xuenou.com/wp-content/themes/chromenews/template-parts/content.php on line 173
TrendRadars
The Most Interesting Articles, Mysteries and Discoveries